The sestiere Cannaregio spans across the northern section of Venice, from the railway station at its West to the church of the Miracoli and Fondamenta Nove at its East to the Rialto Bridge at its South.
Castello is the largest of the six sestiere of Venice and occupies the Eastern half of Venice's historic center. Although Castello is one of the most residential sections of Venice, it holds many important landmarks including the Scuola Grande di San Marco, the Arsenale and the Biennale Gardens (Giardini).
Dorsoduro runs along the south of Venice's historic center and also includes the Islands of Giudecca and Sacca Fisola. Main landmarks include the church of San Sebastiano, Campo Santa Margherita, the Zattere quay that runs along the Giudecca Canal, the Accademia Bridge and Art Museum (Gallerie dell'Accademia), the Peggy Guggenheim Collection and the church of the Salute.
- SANTA CROCE
The eastern half of Santa Croce is known for its quiet residential streets and churches, while the western half contains Piazzale Roma, Venice's bus station and parking area. This sestiere continues to grow with the expansion of Tronchetto, a series of islands that have been developed into additional industrial space and boat yards for large cruise ships.
- SAN MARCO
The sestiere of San Marco lies at the heart of the city, and includes St. Mark's Square - the former location of Venice's government. San Marco runs along the Grand Canal from the eastern foot of the Rialto Bridge through the Accademia Bridge, and continues on to the canal behind the Basilica San Marco and Palazzo Ducale. Other landmarks include the church of San Salvador and the Teatro La Fenice and the Island of San Giorgio Maggiore.
- SAN POLO
Although San Polo is the smallest of the six sestiere of Venice, it is also one of the oldest parts of the city, with settlements dating to before the ninth century. San Polo begins at the western foot of the Rialto Bridge and is home to the Rialto fish and produce markets and includes such landmarks as the churches of San Polo and Santa Maria Gloriosa dei Frari and the Scuola Grande di San Rocco.
- OTHER ISLANDS
The historic center of Venice also encompasses smaller islands throughout the lagoon. North of Venice, Torcello remains the site of the earliest Venetian settlements. Murano is home to the famous glass factories, neighbored by the funerary island of San Michele. Just across the Bacino of San Marco, Palladio's church of San Giorgio Maggiore crowns the island of San Giorgio Maggiore. Lido, the barrier island, protects Venice from the Adriatic Sea, and stretches southward to the island community of Chioggia.