The Pinacoteca Manfrediniana was founded from the art collection of Marquis Federico Manfredini (1743–1829), who devoted his life to assembling paintings and prints while in service to the Grand Dukes of Tuscany and later during his retirement in Veneto. With no heirs, he bequeathed the bulk of his collection to the Patriarchal Seminary of Venice, motivated by his respect for the Venetian patriarchs and his friendship with the scholar Giannantonio Moschini.
The museum preserves 89 works, including pieces by Vivarini, Bellini, Cima da Conegliano, Bassano, Bordone, Lippi, Beccafumi, and Allori, along with examples from central Italian and Northern European schools. Highlights also include early copies of masterpieces now in the Louvre and Hermitage, as well as sculptures and bas-reliefs ranging from the 13th to 19th centuries—notably a 13th-century Adoration of the Magi and terracotta busts by Alessandro Vittoria.
In 2019, the Pinacoteca was officially designated the Diocesan Museum of the Patriarchate of Venice, reinforcing its role as a cultural and spiritual hub in the “Salute” area and safeguarding a significant part of Venice’s artistic heritage.